Fenbendazole
Frequently called Fenben or Panacur, is a benzimidazole class anthelmintic medication. It’s been in use worldwide since its discovery in 1974. (Ref.) During the last few decades it’s been observed that fenbendazole as well as comparable drugs demonstrated a significant anti-cancer impact. (Ref.1, Ref.2)
That brought theories that this listed de-wormer for dogs may be reused as corresponding anti-cancer medication. Actually, benzimidazole class drugs may perform similarly as a broad range of contemporary chemotherapeutic medications like Taxol and vinca alkaloids. (Ref.) The accessible toxicological data indicates that fenbendazole appears to be well accepted in people after oral contact, though there are few studies with humans. (Ref.)
Under typical circumstances, unadulterated fenbendazole is available in a powder format, and is a whitish hue with weak water solubility.
This drug has a low reabsorption in the bowels. Bioavailability may be enhanced by the existence of food in the stomach.
How does fenbendazole work?
Fenbendazole was initially intended to treat parasites by selectively impeding the production of microtubules via fastening to β-tubulin. That prevents the polymerization of tubulin dimers in parasite cells and brings on their death.
Amazingly, it appears fenbendazole along with other types of benzimidazoles shows a comparable effect when pitted against tumor cells. At present it’s believed there are three key methods in how fenbendazole destroys cancer cells:
1) Apoptosis induction. This anti-tumor effect is thought to be done via a collaboration of the medicine with the β-tubulin, which leads to stopping the cell cycle along with being cytotoxic.
Stopping tubulin polymerization into microtubules via benzimidazole carbamates in the helminths as well as in human tumor cells has been well verified. (Ref.1, Ref.2)
2) Stoppage of glucose usage in cancer cells. Cancer cells are well-known for having an immense uptake of glucose. Cancer cells typically use glucose two hundred times quicker than normal cells because of aerobic glycolysis (the Warburg effect). That is revealed in PET scans – the metabolically functional sites, that use additional radioactive glucose is clearly observed and usually believed to be inflammation or cancerous tumors.
Fenbendazole restricts cancer cell feeding with sugar via restricting the uptake of glucose, reducing the quantity of GLUT transporters (channels that bring glucose into the cancerous cells from the blood) as well as the enzyme Hexokinase II. Hexokinase II is crucial for the survival of cancer cells. It supports the tumours and helps them thrive via producing additional sugar and speeding up lactic acidosis inside the extracellular matrix. (Ref.1, Ref.2)
Furthermore, restarting the protein p53 additionally prevents fuel genertion for cancer. When p53 is returned, it prevents the expression and actions of GLUT1 and GLUT4 transporters (glucose gates“) in the cells. (Ref.)
3) Revival of the p53 gene. This work process is yet comparatively controversial, and additional studies must be performed to show fenbendazole triggers this action. (Ref.)
Nevertheless, there’s an escalating amount of research which have confirmed the reality that fenbendazole may actually boost the strongest tumor suppresser in the human body – p53. (Ref.)
It’s understood that an elephant has twenty copies of the p53 gene in its genome but people only have a single copy. Curiously, that’s why an elephant develops cancer less often than people. In spite of these animals being large in size, a bigger number of cells as well as a larger amount of possible genetic mutations.
4) Cancer cells do not create a chemo-opposition to fenbendazole. What is fascinating, cancer cells can’s escape this de-wormer medication and adjust to its existence. Regrettably, this occurs in many more chemotherapy and biological therapy drugs.
The key process of chemoresistance is whenever cancer cells adjust to being able to expel the medications from themselves through unique drug efflux pumps known as P-glycoproteins. Fenbendazole isn’t a target for p-glycoproteins, therefore it can’t be expelled from cancer cells when it gets in them.
Consequently, the tumors do not create any opposition against fenbendazole, it still stays efficient and will still destroy cancer cells, not like paclitaxel, vinblastine, docetaxel, vincristine or additional kinds of chemotherapies. (Ref.)
As can be seen in the image below (Dogra 2018)
5) Fenbendazole can sensitize cancerous tumours to radiotherapy. It can sensitize cancerous tumours to radiotherapy in a comparable way similar to chemotherapy agents in the taxane group. [22].
***Fenbendazole functions like a moderate microtubule disrupting agent and brings on the death of cancer cells
**
Fenbendazole dose guide
Protocol (the initial version) – complimentary treatment of cancer
- Fenbendazole 222 mg. Consume one capsule 3 days weekly, once time daily after eating a fatty dinner. * Then do not take any for 4 days. Replicate this cycle each week.
- Vitamin E 800 U/I. Consume one capsule or another form once daily after eating without any waiting.
- Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
- CBD oil 25 milligrams. Consume one to two drops (total ~25 milligram) under your tongue daily before bedtime.
*- Fenbendazole is actually hydrophobic and it is not absorbed well by the bowels. Consuming this with food or after eating makes it absorb better.
Protocol (the altered, stronger version) – complimentary cancer treatment
- Fenbendazole 222 milligrams. Consume one capsule daily after eating a fatty dinner without waiting. **
- Vitamin E 800 U/I. Consume one capsule or some other version daily without waiting.
- Bio-Available Curcumin 600 mg. Consume one capsule twice daily after eating breakfast and lunch without waiting.
- CBD oil 25 milligrams. Consume one to two drops (total ~25 milligrams) under your tongue daily before bedtime.
** – Fenbendazole is virtually non-toxic to people without no liver or kidney failures.
Avoiding cancer relapse – prophylactic procedure
- Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Replicate this cycle each week.
- Vitamin E 800 U/I. Consume one capsule or some other version daily after eating without stopping.
- Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after you eat breakfast and lunch without stopping.
- CBD oil 25 milligrams. Consume one to two drops (a total of~25 milligrams) under your tongue daily prior to bedtime.
- Tumour marker steady checks every few months, routine annual cancer imaging tests. If there’s not any cancer relapse after five years, reduce the test frequency.
Avoiding cancer for somebody who was always free of cancer – prophylactic procedure
- Fenbendazole 222 milligrams. Consume one capsule 3x weekly, once daily after eating a fatty dinner. Then don’t take it for 4 days. Duplicate this for ten weeks. Halt for ten weeks. Then replicate the cycle once more.
- Vitamin E 800 U/I. Consume one capsule or some other kind daily after eating without stopping.
- Bio-Available Curcumin 600 milligrams. Consume one capsule twice daily after eating breakfast and lunch without stopping.
- CBD oil 25 milligrams. Consume one to two drops (a total of ~25 milligrams) under your tongue daily prior to bedtime.
Safety of Fenbendazole and possible side effects
Centered on toxicology findings, benzimidazoles like Fenbendazole, Albendazole or appear to be safe medications.
Though, a medication with no side-effects doesn’t exist. Scientific information reports don’t show substantial adverse responses from consuming fenbendazole. Still, there are some anecdotal reports of possible toxicity:
- As much as five percent of people may have stomach-aches or loose bowels if they consume large amounts of fenbendazole without a break.
- People who have severe kidney or liver failure have decreased medication excretion levels, consequently, fenbendazole may build up and produce unforeseen side-effects. You should divide the doses based on your circumstances.
The procedure was intended to maintain the liver in optimum health; hence the schedule should be three days on it, and four off is recommended. - When utilized in huge amounts for long timeframes without a break, fenbendazole powder may bring on asymptomatic liver enzyme increases because of the material being mostly metabolized inside the liver. This can be reversed with the assistance of a pause for two weeks.
The procedure was created to maintain the liver in optimum health, hence the schedule of a weekly cycle of three days taking it and four days not taking it is recommended.
Though, increasingly more folks are applying fenbendazole for a timeframe of five days taking it and two days not taking it.
To maintain the liver health ideal, we recommend you consume 250 milligram capsules of Milk Thistle or take 150 milligrams of Silymarin every day as a helpful supplement to maintain it in good shape.
Fenbendazole clinical trials and papers
Another section for scientific pre-clinical papers, as well as in vitro studies on anti-cancer methods, and clinical trials with cancer. Analyze the accessible facts of published studies’ info. A section for info hungry enthusiasts.
To find out more please visit our website: https://fenbenlab.com/
References:
1) Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.
https://www.nature.com/articles/s41598-018-30158-6
2) Unexpected Antitumorigenic Effect of Fenbendazole when Combined with Supplementary Vitamins.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/
3) Fenbendazole as a Potential Anticancer Drug.
http://ar.iiarjournals.org/content/33/2/355.full
4) The Anthelmintic Drug Mebendazole Induces Mitotic Arrest and Apoptosis by Depolymerizing Tubulin in Non-Small Cell Lung Cancer.
https://mct.aacrjournals.org/content/1/13/1201.long
5) Pilot study of albendazole in patients with advanced malignancy. Effect on serum tumor markers/high incidence of neutropenia.
https://www.ncbi.nlm.nih.gov/pubmed/11474247
6) Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: in vitro and in a xenograft model of peritoneal carcinomatosis.
https://www.ncbi.nlm.nih.gov/pubmed/15565325
7) Benzimidazole as Novel Therapy for Hormone-Refractory Metastatic Prostate Cancer.
https://apps.dtic.mil/dtic/tr/fulltext/u2/a545657.pdf
8) Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.
https://www.ncbi.nlm.nih.gov/pubmed/18667591
9) Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer.
https://link.springer.com/article/10.1007%2Fs00280-009-1157-8
10) Repurposing Drugs in Oncology (ReDO) — mebendazole as an anti-cancer agent.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/
11) Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy.
https://pdfs.semanticscholar.org/2b47/0bf133be75b36c09ebc8b17e70cea85fd9af.pdf
12) Chronic myelogenous leukemia in a great horned owl (Bubo virginianus)
https://www.ncbi.nlm.nih.gov/pubmed/19530405
13) Dogra, N. (2018, August 9). Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways. Scientific Reports. https://www.nature.com/articles/s41598-018-30158-6
14) Fenbendazole.org. (2019). Fenbendazole Dosage Guide And Calculator. Scientific Research. https://www.fenbendazole.org/fenbendazole-information/fenbendazole-dosage-guide/
